Global News Appearance for Diabetic Wound Sensing Project

Project Summary:

People living with diabetes are at increased risk of developing wounds, especially on their feet [1]. Once it has occurred, a wound can be challenging to heal and potentially lead to lower limb amputation. Evidence suggests that prevention and better management of these wounds can reduce amputation rates by 85% [2,3]. One potential method of reducing the impact of foot wounds in those with diabetes would be to use biosensors to measure the wound environment directly. We will develop a device incorporating biosensors that are the size of a decimal point.  Each sensor will be able to detect different factors related to wound management such as temperature, electrolytes or pressure. The use of these sensors could enable the early detection of complications, such as infection, when they are less complicated and expensive to treat. In addition, the biosensors would allow clinicians to provide individualized treatments, including selection of wound dressings and methods of pressure relief. This project will develop and test multi-variable biosensors for use on wounds of those living with diabetes. There will be three phases: refinement and lab testing of the biosensors, evaluation of safety and effectiveness in an animal model, and testing on the wounds of patient volunteers.

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References

1. Clayton W, Elasy TA. A review of the pathophysiology, classification, and treatment of foot ulcers in diabetic patients. Clinical diabetes 2009;27(2):52-58.

2. Apelqvist J, Larsson J. What is the most effective way to reduce incidence of amputation in the diabetic foot? Diabetes/metabolism research and reviews 2000;16(S1):S75-S83.

3. Bild DE, Selby JV, Sinnock P, et al. Lower-extremity amputation in people with diabetes: epidemiology and prevention. Diabetes care 1989;12(1):24-31.