Biosensors are becoming more important with increasing demands on health care system. They can provide quick detection of some biomarkers for further testing or prevention of certain health conditions. We develop biosensors in form of wearables, lab-on-chip and point-of-care sensors. Our research group specializes of developing biosensors for diabetic wound sensing and peripheral neuropathy, nutritional sensors as wearables. In addition, we have developed point of care SARS-CoV2 sensors using electrochemical and nano-photonics techniques. We also develop nano pores for biosensing.
Biosensing
Main projects
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More Information can be found here
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To detect diabetic peripheral neuropathy (DPN) we are developing biosensors which will be used to measure the nerve function using the sweat for the measurements. These will allow a person to test themselves at the ease of their home without any preparation for the test and provide results in quickly which can be used to keep track of the individual’s health.
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The research group is developing multi-variate diabetic wound sensors to prevent complications and implant early interventions. The vision is to integrate these in wound bandages for detection of any changes in local wound health and prevent severe outcomes like amputations.
More information can be found here: Biosensors embedded in bandages could monitor diabetic foot wounds to prevent amputations
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Through our research we have developed a COVID-19 diagnostic platform based on aerosol jet-printed antibody-functionalized organic electrochemical transistors (OECTs) for rapidly identifying severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antigens. The goal was to demonstrate an accurate POC biosensor for detecting SARS-CoV-2 antigens, which holds great promise towards developing on-site and at-home rapid SARS-CoV-2 infection screening and COVID-19 prognosis.
Sensing Mechanisms
Electrochemical Sensors
Electrochemical sensors are an excellent way for biosensing. We develop Organic ElectroChemical Transistors (OECTs) for sensing different bioanalytes like glucose, lactate, virus like SARs-CoV2, ions, THC to name a few. OECTs offer an advantage of offering high transconductance which translates to high sensitivity. Most of these sensors are fabricated using additive manufacturing tecjaerosol jet printing.
Photonics
Nanophotonics can be used for develop very sensitive biosensing platforms for low concentration detection using SPR. We utilize FDTD to optimize our designs for Metal Insulator Metal (MIM), metal and quantum material resonators and fabricate them to develop highly sensitive biosensors.
Nanopores
Nanopores are ideal for single molecule detection and can be either biological or solid state. We have developed hybrid nano pores utilizing quantum materials like MoS2 along with barrel proteins like OmpG to develop quite pores.
